| Humoralpathologisches Forschungslabor | Stool test

Immunological parameters

I1 IgA, Faecal secretory immunglobuline A (sIgA)

Included in the nutrition, numerous, potentially infectious and/or antigen working agents enter the intestinal lumen and this penetration of the organism must be prevented. Additionally, the massive colonisation of the body’s own standard flora in the gastrointestinal tract must be considered. On the other hand, the intestine must be permeable for nutritious substances. The gut-associated lymphoid tissue (GALT) will therefore, at an early stage, have a phylogenetic significance for the immune defence.

The secretory immunglobuline A takes an active part in the epithelial cells of the mucous membrane and in the synthesized plasma cells which are located in the sub-epithelial area. In order to get an initial overview of the current functional condition in GALT, sIgA should be defined, which would reflect the secretory ability and degree of stimulation in plasma cells which exist in the intestinal sub-mucosa.
A decreased sIgA value in stool should be taken into account for the following diseases:

  • Allergic diseases (e.g. atopic rhinitis, asthma bronchiale, neurodermatitis, food allergies)
  • Increased infection susceptibility (e.g. relapsing infections in the ear-nose-throat area)
  • Immunosuppressive conditions (e.g. following chemotherapy, radiation)
  • Intestinal mycosis, certain mycoses

Defining faecal sIgA results in immuno-modulative actions, e.g. within the scope of a microbiologic treatment.

Normal value: > 0,7 mg/g stool
Indication of affected gut-associated lymphoid tissue: ≤ 0,7 mg/g stool

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